abstract：:During injection of artificial endolymph into scala media of the guinea pig, fluid pressure was simultaneously measured in endolymph and perilymph with micropipettes. Pressure differences in the order of 10 Pa could reproducibly be measured upon injection of 2-4 microl of artificial endolymph with a rate of 50 nl/s. I...

journal_title：Hearing research

authors： Wit HP,Warmerdam TJ,Albers FW

更新日期：2000-07-01 00:00:00

abstract：:Prior research [Caine et al., 1981] suggested that scopolamine, a central cholinergic antagonist, may increase gap thresholds in young human listeners. If confirmed, an effect of scopolamine on gap detection might help to explain why both aged humans and aged laboratory animals have less sensitive temporal acuity on g...

journal_title：Hearing research

authors： Ison JR,Bowen GP

更新日期：2000-07-01 00:00:00

abstract：:The objective of the present study was to examine whether mepacrine, a commonly used phospholipase A2 inhibitor, decreases ischemic damage to the cochlea. Transient ischemia of the cochlea was induced in albino guinea pigs for 15, 30 or 60 min by pressing the labyrinthine artery at the porus acusticus internus. The an...

journal_title：Hearing research

authors： Tabuchi K,Ito Z,Tsuji S,Wada T,Takahashi K,Hara A,Kusakari J

更新日期：2000-06-01 00:00:00

abstract：:Although gap junctions occur in auditory and vestibular systems, their function is unclear. Here we present evidence for gap junctional communication in transmitting mechanosensory signals in a sea anemone model system. Hair bundles on anemone tentacles are vibration-sensitive mechanoreceptors that regulate discharge ...

journal_title：Hearing research

authors： Mire P,Nasse J,Venable-Thibodeaux S

更新日期：2000-06-01 00:00:00

abstract：:The effects of eliminating the olivocochlear bundle (OCB) on cochlear electromechanical properties were examined by measuring cochlear microphonics (CM) and distortion product otoacoustic emissions (DPOAEs) in chronically de-efferented chinchillas. The OCB fibers to the right ears were successfully sectioned in six ou...

journal_title：Hearing research

authors： Zheng XY,McFadden SL,Henderson D,Ding DL,Burkard R

更新日期：2000-05-01 00:00:00

abstract：:A three-dimensional computer simulation of the experiment (Benser M. E., Issa N.P., Hudspeth A.J., 1993. Hear. Res. 68, 243-252), devoted to the mechanical stimulation of the surface of saccular membrane of bullfrog with the otoconial mass removed was carried out by finite-element method. Comparison of the calculated ...

journal_title：Hearing research

authors： Kondrachuk AV

更新日期：2000-05-01 00:00:00

abstract：:Doppler vibrometers are used by many research groups to monitor the motion of the tympanic membrane (TM) and of middle ear ossicles for in vivo and in vitro studies. Power densities in these applications reach 80 W/cm(2). To determine the safe limit of exposure, a cw dye laser at a wavelength of 633 nm was used to inv...

journal_title：Hearing research

authors： Foth H,Färber S,Gauer A,Wagner R

更新日期：2000-04-01 00:00:00

abstract：:A transmission electron microscopy (TEM) study and synaptophysin immunoreactivity analysis of neurons in the human spiral ganglion was performed with particular emphasis on the demonstration of synapses. The study was based on surgical biopsy material obtained during transcochlear meningioma surgery. Vesiculated nerve...

journal_title：Hearing research

authors： Rask-Andersen H,Tylstedt S,Kinnefors A,Illing R

更新日期：2000-03-01 00:00:00

abstract：:At the synapse between olivocochlear efferent fibers and outer hair cells (OHCs) of the cochlea, a non-classical ionotropic cholinergic receptor allows Ca(2+) entry into the hair cell, thus activating a Ca(2+)-sensitive K(+) current which hyperpolarizes the cell's membrane. In the mammalian ear, this leads to a reduct...

journal_title：Hearing research

authors： Katz E,Verbitsky M,Rothlin CV,Vetter DE,Heinemann SF,Elgoyhen AB

更新日期：2000-03-01 00:00:00

abstract：:The ear of the goldfish (Carassius auratus) contains three otolithic endorgans: the saccule, lagena, and utricle. The saccule has an auditory function in most teleost fishes for whom data are available, and there is evidence that the lagena is also an auditory endorgan in the goldfish. This study was conducted to comp...

journal_title：Hearing research

authors： Edds-Walton PL,Popper AN

更新日期：2000-03-01 00:00:00

abstract：:Recently, many lines of evidence have supported the possibilities that vasopressin (VP) is closely linked to the formation of endolymphatic hydrops in Meniere's disease. In the present study, it was examined whether or not the chronic administration of VP might induce endolymphatic hydrops. For this purpose, histologi...

journal_title：Hearing research

authors： Takeda T,Takeda S,Kitano H,Okada T,Kakigi A

更新日期：2000-02-01 00:00:00

abstract：:Glutamate is the neurotransmitter of the synapse between vestibular type I hair cells and the afferent nerve calyx. This calyx may also be involved in local feedback, which may modify sensory cell activity via N-methyl-D-aspartate (NMDA) receptors. Glycine is the co-agonist of glutamate in NMDA receptor activation. Bo...

journal_title：Hearing research

authors： Devau G

更新日期：2000-02-01 00:00:00

abstract：:In the late stages of inner ear development, the relatively undifferentiated cells of Kollicker's organ are transformed into the elaborately specialized cell types of the organ of Corti. Microtubules are prominent features of adult cells in the organ of Corti, particularly supporting cells. To test the possible role o...

journal_title：Hearing research

authors： Hallworth R,McCoy M,Polan-Curtain J

更新日期：2000-01-01 00:00:00

abstract：:Carboplatin preferentially destroys inner hair cells (IHCs) in the chinchilla inner ear, while retaining a near-normal outer hair cell (OHC) population. The present study investigated the functional consequences of IHC loss on the compound action potential (CAP), inferior colliculus potential (ICP) and auditory cortex...

journal_title：Hearing research

authors： Qiu C,Salvi R,Ding D,Burkard R

更新日期：2000-01-01 00:00:00

abstract：:The avian auditory papilla provides an interesting object on which to study efferent influences, because whereas a significant population of hair cells in birds is not afferently innervated, all hair cells are efferently innervated (Fischer, 1992, 1994a, b). Previous studies in mammals using contralateral sound to sti...

journal_title：Hearing research

authors： Manley GA,Taschenberger G,Oeckinghaus H

更新日期：1999-12-01 00:00:00

abstract：:One objective electrophysiological test for deafness involves presenting a brief acoustic stimulus to a subject and measuring the electrical activity evoked in the muscle located just behind the ear (the post-auricular muscle or PAM). Although this electrical response has been known for many years, it has been ignored...

journal_title：Hearing research

authors： O'Beirne GA,Patuzzi RB

更新日期：1999-12-01 00:00:00

abstract：:The present study examined synaptic potentials of neurons in inferior colliculus (IC) cortex slice and the roles of GABA and glutamate receptors in generating these potentials. Multipolar (82%) and elongated (18%) cells were observed with intracellular biocytin staining. Electrical stimulation of the IC commissure (Co...

journal_title：Hearing research

authors： Li Y,Evans MS,Faingold CL

更新日期：1999-11-01 00:00:00

abstract：:Exposure of the auditory system to either continuous or interrupted nontraumatic noises, often collectively referred to as priming exposures, has been shown, in a number of experimental paradigms, to reduce the susceptibility of the auditory system to noise-induced hearing and sensory cell loss from a subsequent traum...

journal_title：Hearing research

authors： Hamernik RP,Ahroon WA

更新日期：1999-11-01 00:00:00

abstract：:Several studies have been performed in which both the time-dependent and steady state output of cells in the dorsal nucleus of the lateral lemniscus (DNLL) have been measured in response to binaural sound stimulation. In this paper, a mathematical and computational model for the steady state output of DNLL cells is fo...

journal_title：Hearing research

authors： Reed MC,Blum JJ

更新日期：1999-10-01 00:00:00

abstract：:The present study measured interference-response areas (IRAs) for distortion-product otoacoustic emissions (DPOAEs) at 2f(1)-f(2), 3f(1)-2f(2), and 2f(2)-f(1). The IRAs were obtained in either awake or anesthetized rabbits, or in anesthetized guinea pigs and mice, by sweeping the frequencies and levels of an interfere...

journal_title：Hearing research

authors： Martin GK,Stagner BB,Jassir D,Telischi FF,Lonsbury-Martin BL

更新日期：1999-10-01 00:00:00

abstract：:Cochlear outer hair cell (OHC) electromotility is associated with the cell's lateral wall. The lateral wall contains two distinct membranes: the plasma membrane (PM) and the subsurface cisternae (SSC). We explored biophysical characteristics of these lipid structures using membrane-specific fluorescent dyes. We have p...

journal_title：Hearing research

authors： Oghalai JS,Tran TD,Raphael RM,Nakagawa T,Brownell WE

更新日期：1999-09-01 00:00:00

abstract：:The possible presence of different types of delayed rectifier K+ current (I(K)) was studied in vestibular hair cells of frog semicircular canals. Experiments were performed in thin slice preparations of the whole crista ampullaris and recordings were made using the whole-cell patch-clamp technique. We found that an ap...

journal_title：Hearing research

authors： Marcotti W,Russo G,Prigioni I

更新日期：1999-09-01 00:00:00

abstract：:The introduction of foreign genes into cells has become an effective means of achieving intracellular expression of foreign proteins, both for therapeutic purposes and for experimental manipulation. Gene delivery to the nervous system has been extensively studied, primarily using viral vectors. However, to date less w...

journal_title：Hearing research

authors： Derby ML,Sena-Esteves M,Breakefield XO,Corey DP

更新日期：1999-08-01 00:00:00

abstract：:Effects of stimulus level on discrimination of one stimulation site from another were examined in 15 human subjects with Nucleus-22 cochlear implant systems. Bipolar stimulation was used in all cases with electrodes in the bipolar pair separated by 1.5 mm (center to center). Subjects were first tested at a medium loud...

journal_title：Hearing research

authors： Pfingst BE,Holloway LA,Zwolan TA,Collins LM

更新日期：1999-08-01 00:00:00

abstract：:Kanamycin (KM)-induced changes in expression of the gene for glutamate-aspartate transporter (GLAST) in the rat cochlea were analyzed by Northern blotting. With the administration of KM (600 mg/kg/day) once daily for 20 days, the expression of GLAST mRNA gradually increased and reached a peak on day 20. Although the e...

journal_title：Hearing research

authors： Matsuda K,Ueda Y,Doi T,Tono T,Haruta A,Toyama K,Komune S

更新日期：1999-07-01 00:00:00

abstract：:Previous experiments have shown that, in principle, the addition of noise to any vowel coded by an analogue multichannel cochlear implant can enhance the representation of formant information by the temporal pattern of evoked nerve discharges. The optimal addition of noise to some vowel stimuli caused a largely unifor...

journal_title：Hearing research

authors： Morse RP,Evans EF

更新日期：1999-07-01 00:00:00

abstract：:Mammalian aquaporins constitute a family of so far 10 related water channel proteins which mediate osmotically driven water fluxes across the plasma membrane. Because regulation of the ionic composition and osmolality of inner ear fluids is of great functional significance, we investigated the expression patterns of a...

journal_title：Hearing research

authors： Beitz E,Kumagami H,Krippeit-Drews P,Ruppersberg JP,Schultz JE

更新日期：1999-06-01 00:00:00

abstract：:The saccule and the utricle of the vestibular system detect linear acceleration and gravity. Sensory transduction in these organs depends on myriads of calcium carbonate crystals of high specific gravity, called otoconia, embedded in a filament matrix that overlies the sensory epithelium. The coexistence of hard cryst...

journal_title：Hearing research

authors： Kurc M,Farina M,Lins U,Kachar B

更新日期：1999-05-01 00:00:00

abstract：:The cochlear influence of otitis media was investigated in order to identify damaged regions causing cochlear malfunction. BALB/c mice were challenged with viable Streptococcus pneumoniae into the middle ear cavity and were killed 1 day to 1 month later for immunohistochemical analysis. Otitis media was induced in all...

journal_title：Hearing research

authors： Ichimiya I,Suzuki M,Hirano T,Mogi G

更新日期：1999-05-01 00:00:00

abstract：:We are studying the interconnections between the anteroventral cochlear nucleus (AVCN) and the dorsal cochlear nucleus (DCN). Biotinylated dextran was injected into the DCN, where the best frequency of responses was also recorded. Ventrotubercular neurons in AVCN were labeled, along with cochlear nerve fibers and the ...

journal_title：Hearing research

authors： Ostapoff EM,Morest DK,Parham K

更新日期：1999-04-01 00:00:00

abstract：:When auditory nerve function is lost due to surgical removal of bilateral acoustic tumors in cases of neurofibromatosis type 2, a sense of hearing may be restored by means of an auditory brainstem implant (ABI), which electrically stimulates the cochlear nucleus. Electrically evoked auditory brainstem responses record...

journal_title：Hearing research

authors： Waring MD,Ponton CW,Don M

更新日期：1999-04-01 00:00:00

abstract：:The molecular composition and three-dimensional organization of the extracellular matrix (ECM) was studied by immunofluorescent microscopy, transmission and scanning electron microscopy in three connective tissue structures of the cochlea: the spiral limbus, basilar membrane and spiral ligament. Type II collagen, fibr...

journal_title：Hearing research

authors： Tsuprun V,Santi P

更新日期：1999-03-01 00:00:00

abstract：:It is known that adrenocorticotrophic hormone (ACTH)-derived peptides, the so-called melanocortins, can reduce cisplatin-induced neurotoxicity. Recently, our group has found that cisplatin-induced ototoxicity can also be reduced or prevented by treatment with the synthetic melanocortin-like peptide, ORG 2766 (Hamers e...

journal_title：Hearing research

authors： Heijmen PS,Klis SF,De Groot JC,Smoorenburg GF

更新日期：1999-02-01 00:00:00

abstract：:To estimate the correlation between the cochlear lateral wall and endocochlear potential (EP), the EP was measured at different time intervals up to 3 weeks at cochlear focal lesions made in the guinea pig. Lesions were produced by a photochemical reaction between systemically administered Rose Bengal and green light ...

journal_title：Hearing research

authors： Wu R,Hoshino T,Nagura M

更新日期：1999-02-01 00:00:00

abstract：:Membrane-bound guanylyl cyclases (GCs) are peptide hormone receptors whereas the cytosolic isoforms are receptors for nitric oxide. In the inner ear, the membrane-bound GCs may be involved in the regulation of fluid homeostasis and the cytosolic forms possibly play a role in signal processing and regulation of local b...

journal_title：Hearing research

authors： Seebacher T,Beitz E,Kumagami H,Wild K,Ruppersberg JP,Schultz JE

更新日期：1999-01-01 00:00:00

abstract：:Functional magnetic resonance imaging is a noninvasive and nonradioactive method for the detection of focal brain activity. In the present study the auditory cortex was investigated in nine normal subjects who were binaurally stimulated using pulsed sine tones of 500 Hz and 4000 Hz. The BOLD (blood oxygenation level d...

journal_title：Hearing research

authors： Bilecen D,Scheffler K,Schmid N,Tschopp K,Seelig J

更新日期：1998-12-01 00:00:00

abstract：:We performed transient evoked otoacoustic emission (TEOAE) measurements on 29 ears of myasthenia gravis (MG) patients. The purpose of the study was to support the role of acetylcholine (ACh) in the efferent innervation of cochlear outer hair cells (OHCs). Another aim was to establish additional diagnostic tools for th...

journal_title：Hearing research

authors： Tóth L,Rácz T,Diószeghy P,Répássy G,Lampé I

更新日期：1998-12-01 00:00:00

abstract：:We have estimated the transfer curve relating instantaneous sound pressure in the ear canal to instantaneous receptor current through the outer hair cells (OHCs) in the basal turn of the guinea pig cochlea using the cochlear microphonic (CM) elicited by continuous 200 Hz tones. The transfer curve is well approximated ...

journal_title：Hearing research

authors： Patuzzi R,Moleirinho A

更新日期：1998-11-01 00:00:00

abstract：:Membranous vestibular labyrinths from the oyster toadfish, Opsanus tau, were fixed, dissected from the animal, stained, and embedded in rectangular blocks of clear histological resin. Photomicrographs of complete embedded labyrinths were taken from six orthogonal directions and used to construct three-dimensional (3D)...

journal_title：Hearing research

authors： Ghanem TA,Rabbitt RD,Tresco PA

更新日期：1998-10-01 00:00:00

abstract：:The cochlear frequency map is believed to depend on the progressive decrease in partition stiffness from base to apex. Measurements on cochleae from human cadavers by von Békésy (1960) suggested that the elasticity of the partition increases by a factor of 100 from the stapes to the helicotrema. However, conventional ...

journal_title：Hearing research

authors： Naidu RC,Mountain DC

更新日期：1998-10-01 00:00:00